Current insights into familial spastic paraparesis: new advances in an old disease.

@article{Fortini2003CurrentII,
  title={Current insights into familial spastic paraparesis: new advances in an old disease.},
  author={Daniela Fortini and Federica Cricchi and Roberto Di Fabio and Maria Damiano and Giovanna Comanducci and Laura Benedetti and Manuela Valoppi and Gaetano Salvatore Grieco and Ottavio D'Eugenio and Andrea Celato and Filippo Santorelli and Carlo Casali and Giuseppe Amadio Amabile and Francesco Pierelli},
  journal={Functional neurology},
  year={2003},
  volume={18 1},
  pages={
          43-9
        }
}
Hereditary spastic paraparesis (HSP) comprises a clinically and genetically heterogeneous group of disorders characterized by progressive spasticity and hyperreflexia of the lower limbs. The past few years have witnessed an exponential increase in knowledge of this disease and we can now list 19 loci mapped on the human genome and eight genes cloned. However, this wider knowledge of the molecular basis of HSP has had limited impact on clinical practice: the use of antispastic drugs and regular… CONTINUE READING

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