Current insights into LMNA cardiomyopathies: Existing models and missing LINCs

@inproceedings{Brayson2017CurrentII,
  title={Current insights into LMNA cardiomyopathies: Existing models and missing LINCs},
  author={Daniel Brayson and Catherine M Shanahan},
  booktitle={Nucleus},
  year={2017}
}
The nuclear lamina is a critical structural domain for the maintenance of genomic stability and whole-cell mechanics. Mutations in the LMNA gene, which encodes nuclear A-type lamins lead to the disruption of these key cellular functions, resulting in a number of devastating diseases known as laminopathies. Cardiomyopathy is a common laminopathy and is highly penetrant with poor prognosis. To date, cell mechanical instability and dysregulation of gene expression have been proposed as the main… CONTINUE READING
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