Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus.

@article{Mulkey2010CurrentIO,
  title={Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus.},
  author={Daniel K Mulkey and Ian C. Wenker and Orsolya Kr{\'e}neisz},
  journal={Journal of applied physiology},
  year={2010},
  volume={108 5},
  pages={1433-9}
}
Central chemoreception is the mechanism by which CO2/pH-sensitive neurons (i.e., chemoreceptors) regulate breathing in response to changes in tissue pH. A region of the brain stem called the retrotrapezoid nucleus (RTN) is thought to be an important site of chemoreception (23), and recent evidence suggests that RTN chemoreception involves two interrelated mechanisms: H+-mediated activation of pH-sensitive neurons (38) and purinergic signaling (19), possibly from pH-sensitive glial cells. A… CONTINUE READING
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