Current excitement from insect muscarinic receptors

  title={Current excitement from insect muscarinic receptors},
  author={Barry A. Trimmer},
  journal={Trends in Neurosciences},
Recent electrophysiological, pharmacological and molecular studies suggest that muscarinic ACh receptors (mAChRs) in insects are related to, but distinct from, their mammalian counterparts. Insect mAChRs perform two primary roles that are distinguished by their locations. Presynaptic mAChRs, present on sensory terminals, inhibit transmitter release, thereby reducing the effectiveness of specific afferent inputs. In contrast, postsynaptic mAChRs depolarize and increase the excitability of… CONTINUE READING


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