• Corpus ID: 6198096

Current data and strategy in glioblastoma multiforme

@article{Iacob2009CurrentDA,
  title={Current data and strategy in glioblastoma multiforme},
  author={Gabriel Iacob and EB Dinca},
  journal={Journal of Medicine and Life},
  year={2009},
  volume={2},
  pages={386 - 393}
}
  • G. Iacob, EB Dinca
  • Published 15 November 2009
  • Medicine
  • Journal of Medicine and Life
Glioblastoma multiforme (GBM) or astrocytoma grade Ⅳ on WHO classification is the most aggressive and the most frequent of all primary brain tumors. Glioblastoma is multiforme , resistant to therapeutic interventions illustrating the heterogeneity exhibited by this tumor in its every aspect, including clinical presentation, pathology, genetic signature. Current data and treatment strategy in GBM are presented focusing on basic science data and key clinical aspects like surgery, including… 

Tables from this paper

Glioblastoma Multiforme: An Overview of Emerging Therapeutic Targets
TLDR
A review of several promising treatments shown to cross the blood brain barrier and have shown promising pre-clinical results for GBM will outline the status of several of these promising targeted therapies.
Role of Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme
TLDR
The structure, mechanism of action, and rationale of CAR T cell therapy in GBM is explained and various antigenic targets and clinical outcome of initial studies of this novel therapy are discussed.
Glioblastoma Multiforme: A Review of its Epidemiology and Pathogenesis through Clinical Presentation and Treatment
TLDR
It was found that radiation and certain genetic syndromes are the only risk factors identified to date for GBM, and the pathogenesis to involve aberrations of multiple signaling pathways through multiple genetic mutations and altered gene expression.
Glioblastoma Multiforme: A clinico-pathological analysis
TLDR
Histopathology remains the main tool for differentiating the variants of Glioblastoma Multiforme and its variants as radiological differentiation is not possible due to similar appearing features.
Advances in Brain Tumor Surgery for Glioblastoma in Adults
TLDR
Current technologies used for glioma resection, such as awake craniotomy, fluorescence guided surgery, laser interstitial thermal therapy and intraoperative mass spectrometry, and a newly developed tool that has shown promising results in preclinical experiments for brain cancer: optical coherence tomography are described.
GLIOBLASTOMA MULTIFORME: A REVIEW OF ITS PATHOGENESIS AND TREATMENT
  • Z. Banu
  • Medicine
    International Research Journal Of Pharmacy
  • 2019
TLDR
New approaches to study glioblastoma multiforme and to design optimized therapies are greatly required to address the overwhelmingly poor treatment results for patients currently diagnosed with gliOBlastoma.
Glioma and glioblastoma - how much do we (not) know?
TLDR
Investigations are focused on the development of novel methods for improving the outcome of glioblastoma multiforme, which remains one of the most challenging malignancies worldwide.
Molecular Pathogenesis of Glioblastoma in Adults and Future Perspectives: A Systematic Review
TLDR
A systematic review of the literature in the PubMed library suggests targeting therapy at the stemness, p53 mediated pathways and immune modulation in GBM, and exciting novel immune therapy involving dendritic cell vaccines, B-cell vaccines and viral vectors may be the future of treating GBM.
Therapeutics and Research Related to Glioblastoma: Advancements and Future Targets
TLDR
The pathophysiology, neurodegeneration mechanisms, signaling pathways, and future therapeutic targets associated with glioblastomas are described to provide an up-to-date summary of the advancement required in current diagnosis and therapeutics for gliOBlastoma.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Gliomagenesis: genetic alterations and mouse models
  • E. Holland
  • Medicine, Biology
    Nature Reviews Genetics
  • 2001
TLDR
Modelling experiments in mice are helping to delineate the molecular aetiology of glioblastoma multiforme and are providing systems to identify and test novel and rational therapeutic strategies.
Optimal role of temozolomide in the treatment of malignant gliomas
TLDR
Molecular studies suggest a strong predictive role of the DNA repair enzyme O6-methyl-guanine-DNA- methyl-transferase (MGMT) and outcome of TMZbased chemotherapy and this review summarizes the current knowledge, highlights approved and nonapproved indications, and describes molecular studies that may allow us to identify the patients most likely to benefit from this treatment.
Adjuvant chemotherapy in the treatment of high grade gliomas.
Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients.
TLDR
Differences in survival depending on resection status, especially in RPA classes IV and V, support a causal influence of resection on survival.
Recent advances in the molecular genetics of primary gliomas
TLDR
The purpose of this review is to summarize some of the most important recently published findings on the molecular genetics of primary gliomas.
Brainstem Tumors: Where Are We Today?
TLDR
The current classification of brainstem tumors, current management options and future directions for the treatment of these rare tumors are reviewed.
Genetic pathways to primary and secondary glioblastoma.
TLDR
Primary and secondary glioblastomas constitute distinct disease subtypes, affecting patients of different age and developing through different genetic pathways, and differ significantly in their pattern of promoter methylation and in expression profiles at RNA and protein levels.
PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.
TLDR
PTEN mutation and EGFR amplification are important prognostic factors in patients with anaplastic astrocytoma and in older patients with glioblastoma multiforme, respectively.
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
TLDR
The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.
Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme
TLDR
Chloroquine, in conjunction with other treatments, may prolong survival in patients with glioblastoma multiforme by administering chloroquine in addition to surgery and to the standard courses of radiotherapy and chemotherapy.
...
1
2
3
4
5
...