Current concepts of thymic aging

  title={Current concepts of thymic aging},
  author={Terry J Fry and Crystal L Mackall},
  journal={Springer Seminars in Immunopathology},
The absolute requirement for the thymus in primary T cell development was established by Miller in the early 1960s [47] and remains a fundamental tenet of modern immunology. However, in contrast to its role in primary T cell development, obvious clinical immunodeficiency does not result when the thymus is removed after the 5th day of life in mice [47] and 6 months of age in humans [8]. This is due to the fact that peripheral T cell pools are maintained throughout life largely through a variety… CONTINUE READING
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The effect of thymic function on immunocompetence following bone marrow transplantation

  • K Weinberg, G Annett, A Hashyap
  • Biol Blood Marrow Transplant
  • 1995
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