Current concepts of the pathogenesis and management of diabetic ketoacidosis (DKA).

@article{Yan1983CurrentCO,
  title={Current concepts of the pathogenesis and management of diabetic ketoacidosis (DKA).},
  author={Ping Wang Yan and Jin Seng Cheah and Ah Chuan Thai and Patricia Yeo},
  journal={Annals of the Academy of Medicine, Singapore},
  year={1983},
  volume={12 4},
  pages={
          596-605
        }
}
Diabetic ketoacidosis (DKA) is the commonest endocrine emergency encountered in clinical practice. Although in the last 3 decades the average worldwide immediate mortality has decreased from 10% to 5%, survival has not improved strikingly. The pathogenesis of DKA is currently attributed to a combination of two hormonal abnormalities--a relative insulin insufficiency and stress hormone excess (glucagon, catecholamines, cortisol and growth hormone). Withdrawal of exogenous insulin, pancreatic… CONTINUE READING