Current concepts of blood-brain barrier development.

  title={Current concepts of blood-brain barrier development.},
  author={Stefan Liebner and Cathrin J. Czupalla and Hartwig Wolburg},
  journal={The International journal of developmental biology},
  volume={55 4-5},
Homeostasis of the central nervous system (CNS) microenvironment is essential for its normal function and is maintained by the blood-brain barrier (BBB). The BBB proper is made up of endothelial cells (ECs) interconnected by tight junctions (TJs) that reveal a unique morphology and biochemical composition of the body's vasculature. In this article, we focus on developmental aspects of the BBB and describe morphological as well as molecular special features of the neuro-vascular unit (NVU… CONTINUE READING