Current concepts in the pathogenesis of age-related macular degeneration.

@article{Zarbin2004CurrentCI,
  title={Current concepts in the pathogenesis of age-related macular degeneration.},
  author={Marco Attilio Zarbin},
  journal={Archives of ophthalmology},
  year={2004},
  volume={122 4},
  pages={598-614}
}
OBJECTIVE To review and synthesize information concerning the pathogenesis of age-related macular degeneration (AMD). METHODS Review of the English-language literature. RESULTS Five concepts relevant to the cell biology of AMD are as follows: (1) AMD involves aging changes plus additional pathological changes (ie, AMD is not just an aging change); (2) in aging and AMD, oxidative stress causes retinal pigment epithelial (RPE) and, possibly, choriocapillaris injury; (3) in AMD (and perhaps in… CONTINUE READING
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