Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy.

  title={Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy.},
  author={Yao Wang and Terry J Smith},
  journal={Investigative ophthalmology & visual science},
  volume={55 3},
  • Yao Wang, Terry J Smith
  • Published 2014 in Investigative ophthalmology & visual science
  • DOI:10.1167/iovs.14-14002
Graves' disease (GD) is a common autoimmune condition. At its core, stimulatory autoantibodies are directed at the thyroid-stimulating hormone receptor (TSHR), resulting in dysregulated thyroid gland activity and growth. Closely associated with GD is the ocular condition known as thyroid-associated ophthalmopathy (TAO). The pathogenesis of TAO remains enigmatic as do the connections between the thyroid and orbit. This review highlights the putative molecular mechanisms involved in TAO and… CONTINUE READING

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