Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report

@article{Malfertheiner2006CurrentCI,
  title={Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report},
  author={Peter Malfertheiner and Francis M{\'e}graud and C O'Morain and Franco Bazzoli and Emad M El-Omar and David Yates Graham and R H Hunt and Theodoros Rokkas and Nimish Vakil and Ernst J. Kuipers},
  journal={Gut},
  year={2006},
  volume={56},
  pages={772 - 781}
}
Background: Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000. Aims: To update the guidelines at the European Helicobacter Study Group (EHSG) Third Maastricht Consensus Conference, with emphasis on the potential of H pylori eradication for the prevention of gastric cancer. Results: Eradication of H pylori infection is recommended in (a) patients with gastroduodenal diseases such as peptic ulcer disease and… 
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References

SHOWING 1-10 OF 243 REFERENCES
Strategy for treatment of Helicobacter pylori infection in adults. I. Updated indications for test and eradication therapy suggested in 2000.
TLDR
Intervention studies are now in progress to test the hypothesis that prevention of gastric malignancy is an outcome of H. pylori eradication, and the acceptable indications of eradication therapy will vary among countries.
Current European concepts in the management of Helicobacter pylori infection--the Maastricht Consensus Report. The European Helicobacter Pylori Study Group (EHPSG).
TLDR
There was consensus that treatment regimens should be simple, well tolerated and achieve an eradication rate of over 80% on an intention to treat basis.
Helicobacter pylori infection and gastro-oesophageal reflux disease: coincidence or association?
TLDR
Eradication of H. pylori infection appears advisable in patients on long-term proton pump inhibitors and an increase of inflammatory activity in fundic and corpus mucosa is a consistent phenomenon, in the authors' opinion.
Symptomatic benefit 1–3 years after H. pylori eradication in ulcer patients: impact of gastroesophageal reflux disease
TLDR
A substantial proportion of ulcer patients have symptoms and/or signs of coexisting gastroesophageal reflux disease (GERD) at initial presentation and this reduces the symptomatic benefit from H. pylori eradication, and there is no evidence that eradicating H.pylori induces de novo GERD symptoms in ulcers patients.
Helicobacter pylori test-and-eradicate versus prompt endoscopy for management of dyspeptic patients: a randomised trial
Canadian Helicobacter Study Group Consensus Conference on the Approach to Helicobacter pylori Infection in Children and Adolescents.
TLDR
Diagnostic tests should be employed judiciously and be reserved for children who are most likely to derive measurable benefit, such as those likely to have peptic ulcer disease.
Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation.
TLDR
An evidence-based appraisal of 14 topics was undertaken in a consensus conference to update guidelines based on the best available evidence using an established and uniform methodology to address and formulate recommendations for each topic.
Management of Peptic Ulcers: Emerging Issues
  • J. Freston
  • Medicine, Biology
    World Journal of Surgery
  • 2000
TLDR
Evidence suggests that H. pylori eradication may foster the development of erosive esophagitis, but confirmatory studies are needed and studies also suggest an interaction between H. Pylori infection and peptic ulcers related to the use of nonsteroidal antiinflammatory drugs (NSAIDs).
Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial
TLDR
Most H pylori positive GORD patients have a corpus predominant pangastritis during omeprazole maintenance therapy and should be eradicated, according to the Sydney classification system.
Is Eradication Therapy Useful as the First Line of Treatment in Helicobacter pylori-Positive Idiopathic Thrombocytopenic Purpura? Analysis of 207 Eradicated Chronic ITP Cases in Japan
TLDR
H pylori infection was involved in most ITP patients older than 40 years in Japan, and eradication therapy should be the first line of treatment in H pylonori-positive ITP Patients.
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