Current concepts in genetics of nonsyndromic clefts

  title={Current concepts in genetics of nonsyndromic clefts},
  author={J S Satyanarayana Murthy and Lakkakula VKS Bhaskar},
  booktitle={Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India},
Nonsyndromic cleft lip and palate is a complex genetic disorder with variable phenotype, largely attributed to the interactions of the environment and multiple genes, each potentially having certain effects. Numerous genes have been reported in studies demonstrating associations and/or linkage of the cleft lip and palate phenotypes to alleles of microsatellite markers and single nucleotide polymorphisms within specific genes that regulate transcription factors, growth factors, cell signalling… CONTINUE READING
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