Current clinical use of reteplase for thrombolysis. A pharmacokinetic-pharmacodynamic perspective.

@article{Martin1999CurrentCU,
  title={Current clinical use of reteplase for thrombolysis. A pharmacokinetic-pharmacodynamic perspective.},
  author={Una Martin and Beat Kaufmann and G. Neugebauer},
  journal={Clinical pharmacokinetics},
  year={1999},
  volume={36 4},
  pages={265-76}
}
Clinical evaluation of a new thrombolytic agent should start with a dose that provides adequate efficacy and has an acceptably low bleeding risk; this results in a narrow therapeutic window at the upper end of the dose-response curve. Angiographic patency of the infarct-related artery is still the clinical surrogate end-point for mortality in phase II dose-ranging studies. There is experimental and clinical evidence that the area under the concentration-time curve (AUC) for plasminogenolytic… CONTINUE READING
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