Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative.

@article{Piccini2009CurrentCI,
  title={Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative.},
  author={Jonathan P Piccini and David Joshua Whellan and Brian R. Berridge and John K Finkle and Syril D. Pettit and Norman L. Stockbridge and J G Valentin and Hugo M. Vargas and Mitchell W. Krucoff},
  journal={American heart journal},
  year={2009},
  volume={158 3},
  pages={317-26}
}
In October 2008, in a public forum organized by the Cardiac Safety Research Consortium and the Health and Environmental Sciences Institute, leaders from government, the pharmaceutical industry, and academia convened in Bethesda, MD, to discuss current challenges in evaluation of short- and long-term cardiovascular safety during drug development. The current paradigm for premarket evaluation of cardiac safety begins with preclinical animal modeling and progresses to clinical biomarker or… CONTINUE READING

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