Current challenges and solutions of de novo assembly

@article{Liao2019CurrentCA,
  title={Current challenges and solutions of de novo assembly},
  author={Xingyu Liao and Min Li and You Zou and F. X. Wu and Yi-Pan and Jianxin Wang},
  journal={Quantitative Biology},
  year={2019},
  volume={7},
  pages={90-109}
}
BackgroundNext-generation sequencing (NGS) technologies have fostered an unprecedented proliferation of high-throughput sequencing projects and a concomitant development of novel algorithms for the assembly of short reads. However, numerous technical or computational challenges in de novo assembly still remain, although many new ideas and solutions have been suggested to tackle the challenges in both experimental and computational settings.ResultsIn this review, we first briefly introduce some… CONTINUE READING
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