Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage.

@article{Muniyappa2008CurrentAF,
  title={Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage.},
  author={Ranganath Muniyappa and Sihoon Lee and Hui Chen and M. Quon},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={294 1},
  pages={
          E15-26
        }
}
Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying insulin sensitivity/resistance in humans and animal models is of great importance for epidemiological studies, clinical and basic science investigations, and eventual use in clinical practice. Direct and indirect methods of varying complexity are currently employed for these purposes. Some methods rely on steady-state… 

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