Current anticoagulant therapy--unmet clinical needs.

@article{Hirsh2003CurrentAT,
  title={Current anticoagulant therapy--unmet clinical needs.},
  author={Jack Hirsh},
  journal={Thrombosis research},
  year={2003},
  volume={109 Suppl 1},
  pages={S1-8}
}
Heparin and the vitamin K antagonist warfarin have been in clinical use for more than 50 years. However, both are associated with several well-documented drawbacks that limit their use. Warfarin can be administered orally, making it the agent of choice for long-term management of thromboembolic conditions, but frequent coagulation monitoring is necessary because of its unpredictable anticoagulant effect--the result, in part, of food and drug interactions-and its narrow therapeutic window… CONTINUE READING
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