Current and investigational drug strategies for glioblastoma.

  title={Current and investigational drug strategies for glioblastoma.},
  author={Mazhar Ajaz and S J Jefferies and Linda Brazil and Colin Watts and Anthony J Chalmers},
  journal={Clinical oncology (Royal College of Radiologists (Great Britain))},
  volume={26 7},
Medical treatments for glioblastoma face several challenges. Lipophilic alkylators remain the mainstay of treatment, emphasising the primacy of good blood-brain barrier penetration. Temozolomide has emerged as a major contributor to improved patient survival. The roles of procarbazine and vincristine in the procarbazine, lomustine and vincristine (PCV) schedule have attracted scrutiny and several lines of evidence now support the use of lomustine as effective single-agent therapy. Bevacizumab… CONTINUE READING
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