Current and future trends in the prevention, treatment and control of rabies

  title={Current and future trends in the prevention, treatment and control of rabies},
  author={Charles E. Rupprecht and Rodney E. Willoughby and Dennis Slate},
  journal={Expert Review of Anti-infective Therapy},
  pages={1021 - 1038}
Rabies remains a global zoonosis of major public health, agricultural and economic significance. Dogs are the major animal reservoirs in developing regions, wildlife maintain cycles of infection even in developed countries and new viral etiological agents continue to emerge. Nearly all human rabies cases are related directly to animal bite and thus, primary disease prevention requires minimization of suspected exposures. Once exposure occurs, modern prophylaxis entails immediate wound care… 

An overview of rabies - history, epidemiology, control and possible elimination.

Progress toward eliminating rabies has been markedly faster in nations that have emphasized preventive vaccination of animals, and the chief obstacle to eradicating rabies especially in bats is that no one has developed an aerosolized vaccine that could be sprayed into otherwise inaccessible caves and tree trunks.

Elimination of Rabies : A Missed Opportunity

This chapter emphasizes that, given the global epidemiology of rabies, the “One Health” concept is key to solving the problem and that human rabies can only be eliminated through rabies control at the animal source.

Travel vaccination for rabies

Travelers to countries where rabies is prevalent should balance the cost and inconvenience of immunization to the benefits of rabies pre-exposure vaccination.

Rabies: Virus and Disease

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Evaluation of long-term protective efficacy of rabies vaccines in dogs

It is indicated that a single shot of rabies vaccine can protect dogs for up to six years, and six-year vaccinated dogs induced better cellular immune responses than other dogs.

Rabies Vaccines: Its Role, Challenges, Considerations and Implications for the Global Control and Possible Eradication of Rabies

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In the clinical setting the Antirabies Vaccination (ARV) OPD, Sir J.J. Hospital, Mumbai, the Intradermal regime was cost effective and increased patient adherence and enrolment and the vaccine cost for i.d. was reduced.

Rabies in the Caribbean: A Situational Analysis and Historic Review

The insularity of the Caribbean makes it ideal for conducting pilot studies on reservoir host population management, and best practice guidelines developed for these reservoir hosts can be individually modified to the epidemiological status and available resources within each locality.



Economics of human and canine rabies elimination: guidelines for programme orientation.

In countries where resources allocated to rabies control are inadequate in both the health and veterinary sectors, the comparison in costs and effectiveness of the two programme strategies for rabies elimination strongly suggests that consideration should be given to a national programme of dog Rabies elimination.

New approaches to the prevention and eradication of rabies

The structural requirements for an effective rabies vaccine, as well as new strategies currently in use for the development of safer and more potent rabies vaccines for rabies prophylaxis and eradication are discussed.

Rabies and rabies-related viruses: a modern perspective on an ancient disease.

The epidemiology of bat rabies should be fully explored, so that the precise risks to the health of humans and domestic and wild carnivores may be determined and methods of preventing the disease among people who handle bats can be discovered.

Re-evaluating the burden of rabies in Africa and Asia.

Rabies remains an important yet neglected disease in Africa and Asia, and disparities in the affordability and accessibility of post-exposure treatment and risks of exposure to rabid dogs result in a skewed distribution of the disease burden across society.

A case of human rabies in Kansas: epidemiologic, clinical, and laboratory considerations.

The case of human rabies presented here is a nervous system with certain time-honored epidemiologic, clinical, and laboratory characteristics and is generally believed to rule out rabies.

Recovery of a patient from clinical rabies--Wisconsin, 2004.

This is the first documented recovery from clinical rabies by a patient who had not received either pre- or postexposure prophylaxis for rabies.

Comparison of an anti-rabies human monoclonal antibody combination with human polyclonal anti-rabies immune globulin.

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Field trial with oral vaccination of dogs against rabies in the Philippines

The results of the campaign show that oral vaccination of dogs against rabies is a promising supplementary method in dog rabies control in the Philippines.

Results of an oral rabies vaccination program for coyotes.

The number of rabies cases in the target area decreased, and expansion of the epizootic area ceased, and mass distribution of an oral rabies vaccine in a palatable bait is an effective means to halt expansion of a rabies epizootsic involving coyotes.