Current and future treatments in progressive supranuclear palsy

@article{Balken2006CurrentAF,
  title={Current and future treatments in progressive supranuclear palsy},
  author={Irene van Balken and Irene Litvan},
  journal={Current Treatment Options in Neurology},
  year={2006},
  volume={8},
  pages={211-223}
}
Opinion statementProgressive supranuclear palsy (PSP) is an atypical parkinsonian disorder that, in spite of its growing recognition, is still underdiagnosed. For management, prognosis, and research, an accurate and early diagnosis is essential. PSP is a relentlessly progressive neurodegenerative disorder, clinically characterized by parkinsonism with prominent axial involvement and postural instability, bulbar symptoms, supranuclear ophthalmoplegia, and executive dysfunction. Abnormal neuronal… Expand
Therapeutic options for Progressive Supranuclear Palsy including investigational drugs
TLDR
The most important therapeutic targets for PSP patients are discussed based on the hypothesized pathogenesis of the disease and most of the current symptomatic therapeutic approaches are based on small double-blind, placebo control studies, or open trials. Expand
A Review of Treatment Options for Progressive Supranuclear Palsy
TLDR
The evidence on pharmacotherapy and experimental therapies ingressive supranuclear palsy is reviewed and levels of recommendation for the off-label use of commonly used drugs in this disorder are provided. Expand
Preclinical, phase I, and phase II investigational clinical trials for treatment of progressive supranuclear palsy
TLDR
Disease-modifying therapeutic options which are currently under evaluation or have been evaluated in preclinical or clinical trials based on their targeted pathophysiologic process are discussed. Expand
Title Preclinical , phase I , and phase II investigational clinical trials for treatment of progressive supranuclear palsy
Introduction: Our understanding of the pathological basis of progressive supranuclear palsy (PSP), as the most common atypical parkinsonian syndrome, has greatly increased in recent years and aExpand
Mitochondrial Dysfunction as a Therapeutic Target in Progressive Supranuclear Palsy
TLDR
It is suggested that a failure in mitochondrial energy production might act as an upstream event in the chain of pathological events leading to the aggregation of tau and neuronal cell death in PSP. Expand
Concomitant Medication Use in Progressive Supranuclear Palsy Clinical Trial Participants
Progressive Supranuclear Palsy (PSP) is a rare and progressive movement disorder pathologically characterized by tau tangles for which there are no effective therapies. Emerging therapies forExpand
Interventions in progressive supranuclear palsy.
Progressive supranuclear palsy (PSP) an atypical parkinsonian with a common phenotype comprising early falls, the characteristic slowing of vertical saccades and a frontal syndrome with marked apathyExpand
Current and future therapeutic approaches in progressive supranuclear palsy.
TLDR
Since an effective therapy for PSP has yet to be found, current management should include palliative symptomatic therapies, education, and support for patients and caregivers to improve the quality of life of patients and their caregivers. Expand
Frontotemporal lobar degeneration
TLDR
The clinical and pathological heterogeneity of FTLD poses a significant diagnostic challenge, and in vivo prediction of underlying histopathology can be significantly improved by supplementing the clinical evaluation with genetic tests and emerging biological markers. Expand
Functional impairment in progressive supranuclear palsy
TLDR
Function disability was high in early-stage PSP, with 100% of patients having less than perfect scores on all functional scales, and the definition of functional intactness/impairment has important implications. Expand
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TLDR
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