Current and emerging second-generation triptans in acute migraine therapy: a comparative review.

@article{Deleu2000CurrentAE,
  title={Current and emerging second-generation triptans in acute migraine therapy: a comparative review.},
  author={Dirk T Deleu and Yolande I Hanssens},
  journal={Journal of clinical pharmacology},
  year={2000},
  volume={40 7},
  pages={687-700}
}
Sterile neurogenic inflammation within cephalic tissue, involving vasodilation and plasma protein extravasation, has been proposed as a pathophysiological mechanism in acute migraine. The action of 5-hydroxytryptamine (5-HT1B/1D) agonists--so-called triptans--on receptors located in meningeal arteries (5-HT1B) and trigeminovascular fiber endings (5-HT1D) has an inhibitory effect on this neurogenic inflammation. Recently, a series of second-generation 5-HT1B/1D agonists (almotriptan, eletriptan… CONTINUE READING

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