Current and Investigational Medication Delivery Systems for Treating Attention-Deficit/Hyperactivity Disorder.
@article{Jain2016CurrentAI, title={Current and Investigational Medication Delivery Systems for Treating Attention-Deficit/Hyperactivity Disorder.}, author={Rakesh K. Jain and Alain Katic}, journal={The primary care companion for CNS disorders}, year={2016}, volume={18 4} }
OBJECTIVE
To review currently available formulations and emphasize unmet needs in the pharmacologic management of attention-deficit/hyperactivity disorder (ADHD).
DATA SOURCES
Publications and clinical trials were identified through PubMed and ClinicalTrials.gov, respectively. A Web-based search identified prescribing information for approved agents for treating ADHD, along with relevant guidelines and diagnostic criteria.
STUDY SELECTION
The following search terms were used: (1) ADHD or…
15 Citations
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Efficacy and Safety of SHP465 Mixed Amphetamine Salts in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: Results of a Randomized, Double-Blind, Placebo-Controlled, Forced-Dose Clinical Study
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Evaluating the efficacy and safety of SHP465 mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder (ADHD) found that the percentage of participants categorized as improved on Clinical Global Impressions-Improvement was higher with both SHP 465 MAS doses than with placebo (both nominal p < 0.001).
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In this chapter, the authors discuss both established and novel pharmacological treatment and neuromodulation in treatment-resistant ADHD.
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This study suggests that children with more ADHD symptoms may be at higher risk of an unhealthy diet but that overall diet quality does not affect ADHD risk.
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Population Pharmacokinetic-Pharmacodynamic Modeling of a Novel Methylphenidate Extended-Release Orally Disintegrating Tablet in Pediatric Patients With Attention-Deficit/Hyperactivity Disorder
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A population pharmacokinetic (PK)/pharmacodynamic (PD) model is developed to describe MPH XR-ODT PD-response data in a classroom study and use the model to simulate PD responses for a range of body weights and doses to help facilitate the dose-titration process.
A randomized, double-blind study of SHP465 mixed amphetamine salts extended-release in adults with ADHD using a simulated adult workplace design
- MedicinePostgraduate medicine
- 2018
SHP465MAS (combined 50/75 mg) significantly improved PERMP total score versus placebo, with superiority observed from 2 to 16 h postdose, and the tolerability profile of SHP465 MAS was similar to previous reports of SHp465 MAS in adults with ADHD.
Effects of SHP465 mixed amphetamine salts in adults with ADHD in a simulated adult workplace environment
- MedicinePostgraduate medicine
- 2018
SHP465 MAS (25 mg) was superior to placebo on PERMP total score, with treatment differences observed from 4 to 16 hours postdose; nominal treatment differences on the ADHD-SRS, but not the Co-ADHD-RS TSRS, were also observed.
Effects of medications on ventricular repolarization in children with attention deficit hyperactivity disorder
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Attention deficit hyperactivity disorder (ADHD) is a multifactorial neurodevelopmental disorder that manifests during childhood. Methylphenidate (MPH), which is a psychostimulant drug, has been often…