Current Understanding of the Role of PPARγ in Gastrointestinal Cancers

  title={Current Understanding of the Role of PPARγ in Gastrointestinal Cancers},
  author={Bing Zou and Liang Qiao and Benjamin Chun-yu Wong},
  booktitle={PPAR research},
Numerous studies have indicated that PPARγ plays multiple roles such as in inflammation, cell cycle control, cell proliferation, apoptosis, and carcinogenesis, thus PPARγ contributes to the homeostasis. Many in vitro studies have showed that ligand-induced activation of PPARγ possess antitumor effect in many cancers including CRC. However, the role of PPARγ in gastrointestinal cancers, especially in colorectal cancer, is rather controversial. Nevertheless, some recent studies with the positive… CONTINUE READING


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