Current Understanding of Atherogenesis.

  title={Current Understanding of Atherogenesis.},
  author={Richard A Brown and E Shantsila and Chetan Varma and Gregory Y. H. Lip},
  journal={The American journal of medicine},
  volume={130 3},
Scientific understanding of atherogenesis is constantly developing. From Virchow's observations 160 years ago we now recognize the endothelial response to injury as inflammatory, involved in all stages of atherosclerosis. Endothelial activation may cause reversible injury or dysfunction, or lead to irreparable damage. Indeed, early atherosclerosis is reversible. The introduction of genome-wide association testing has furthered the identification of potentially important genetic variants that… CONTINUE READING