Current Status of the Vel Blood Group System

  title={Current Status of the Vel Blood Group System},
  author={Leon N. Sussman},
A review of the Vel blood group system reveals that 19 thoroughly studied examples of anti‐Vel are known and at least 50 Vel negative persons are recorded. The frequency of the Vel negative person is 0.04 per cent. All cases to date have been in Caucasians. The antigen is poorly developed in cord blood, but retains reactivity in the aged, on storage at 4 C, as well as after freezing. An associated hemolysin is usually not reactivated by addition of complement after inactivation. Bromelin… 
Disruption of SMIM1 causes the Vel− blood type
The biochemical and genetic basis of the Vel blood group antigen, which has been a vexing mystery for decades, is reported and two highly specific DNA‐based tests for rapid Vel genotyping, which can be easily integrated into blood group genotypesing platforms are developed.
Disruption of SMIM 1 causes the Vel S blood type
The biochemical and genetic basis of the Vel blood group antigen, which has been a vexing mystery for decades, is reported and two highly specific DNA-based tests for rapid Vel genotyping are developed, which can be easily integrated into blood group genotypesing platforms.
Blood Groups of the Thais
Blood and saliva from 456 unselected blood donors from the Siriraj Hospital, Bangkok were studied and evidence for the presence of Jk was found in three of the 15 families studied but no Jk(a—b—) phenotypes were encountered.
Prenatal assessment of blood group antibodies against "public" antigens. An example of anti-Ve (Vel) in pregnancy.
The results of the serological and immunological investigations were negative, and no maternal antibody was present in the infant's serum, and the difficulty in assessing whether an infant is likely to be affected when such antibodies are present in pregnancy is stressed.
Hematologic complications in a patient with Glycine soja polyagglutination following fresh frozen plasma transfusion
The patient’s confounding hematologic complications can best be explained by polyagglutination, which developed secondary to the severe MRSA infection, and needs to be recognized to appropriately manage hemotherapy.
SMIM1 at a glance; discovery, genetic basis, recent progress and perspectives
The Vel Blood Group in Northern Sweden
A detailed study of the Vel blood group has been made in the Northern region of Sweden, showing Vel to be independent of P1, though some association with P groups was detected since P2 was more frequent amongst Vel(‐) than expected.
The Polymorphism of SMIM1 Gene in Chinese Dividuals
The allele at intron 3 position 193 was the most frequent mutant allele found in the Chinese population and Vel antigen deficiency may not cause problems in Chinese patients with hematological diseases and RBC autoantibodies.
Zwei Geschwister mit Anti-Vel
Family investigation showed that a sister of the patient was also Velnegative, and an anti-Vel antibody was found in the serum, and the haemolytic effect of the weaker serum could only be demonstrated with enzyme-treated erythrocytes.
SMIM1 missense mutations exert their effect on wild type Vel expression late in erythroid differentiation
How SMIM1 expression is regulated during erythropoiesis is reported, to understand its variable expression on erythrocytes.


Seven Vea (Vel) Negative Members in Three Generations of a Family
A family with seven Vel negative (VeVe) members in three generations was found because the propositus had a hemolytic transfusion reaction, and study of the blood groups of the family shows that Vea is not in the MNS system.
Further Studies of the I Antigen and Antibody
The blood of a Puerto Rican, of a West Indian Negress and of several members of a Baltimore Negro family is described. The red cells of these people are apparently of the phenotype i and their serum
Two Sisters Lacking the Blood Group Antigen Vel
The first published evidence that the Vel antigen of Sussman and Miller is, as anticipated, under genetic control is provided, and it is demonstrated that theVel antigens does not belong to the ABO, secretor or Kidd systems of blood groups.
Inheritance of Blood Groups
This book is strongly recommended to all who take an intelligent interest in the problems of the nature of man and his relationship to the world.
The inheritance of blood groups.
Another example of anti-Vel.
Blood Groupings in Marshallese
The absence of the Diego blood factor, the extremely low incidence of the M gene, and the unusually high R1 gene frequency of the Marshallese more nearly resemble the blood groupings of the people of