Current State of the Diagnosis of Invasive Pulmonary Aspergillosis in Lung Transplantation

@article{Herrera2019CurrentSO,
  title={Current State of the Diagnosis of Invasive Pulmonary Aspergillosis in Lung Transplantation},
  author={Sabina Herrera and Shahid Husain},
  journal={Frontiers in Microbiology},
  year={2019},
  volume={9}
}
As the number of lung transplants performed worldwide each year continues to grow, the success of this procedure is threatened by the incidence of non-CMV infections such as invasive aspergillosis. Despite tremendous efforts and the availability of numerous diagnostic tests (especially in hematological malignancies) the diagnosis of invasive aspergillosis continues to be a challenge. Lung transplantation remains a unique clinical scenario, where additional host defenses are immunocompromized… 
6 Citations

Figures and Tables from this paper

Monoclonal Antibodies and Invasive Aspergillosis: Diagnostic and Therapeutic Perspectives

TLDR
This review summarizes the up-to-date application of mAb-based approaches in assisting IA diagnosis and therapy and suggests monoclonal antibodies with high specificity in targeting the corresponding antigen(s) may have the potential to improve diagnostic tests and form the basis for novel IA treatments.

Challenges in Serologic Diagnostics of Neglected Human Systemic Mycoses: An Overview on Characterization of New Targets

TLDR
The current context of the diagnosis of the main systemic mycoses is discussed, and alternative approaches for the identification of new targets for fungal pathogens are proposed, which can help in the development of new diagnostic tests.

Two Monoclonal Antibodies That Specifically Recognize Aspergillus Cell Wall Antigens and Can Detect Circulating Antigens in Infected Mice

TLDR
Both 1D2 and 4E4 mAbs are potentially promising diagnostic tools to investigate invasive aspergillosis and may provide a platform for a new diagnostic approach.

Aspergillus and Aspergillosis

References

SHOWING 1-10 OF 99 REFERENCES

Early diagnosis of fungal infections in lung transplant recipients, colonization versus invasive disease?

TLDR
Efforts are being made to develop new tools that will allow us to identify which patients will develop IPA, and those who will be able to control the disease.

The use of respiratory-tract cultures in the diagnosis of invasive pulmonary aspergillosis.

Laboratory diagnosis of invasive aspergillosis.

Efficacy of PTX3 in a Rat Model of Invasive Aspergillosis

TLDR
The protective activity of PTX3 in pulmonary aspergillosis is extended to corticosteroid-induced immunodeficiency, which is a relevant clinical condition in graft-versus-host disease and in solid organ transplant.

Evaluation of Bronchoalveolar Lavage Fluid Cytokines as Biomarkers for Invasive Pulmonary Aspergillosis in At-Risk Patients

TLDR
Findings highlight the existence of a specific profile of alveolar cytokines, with IL-8 being the dominant discriminator, which might be useful in supporting current diagnostic approaches for IPA.

The isolation of Aspergillus fumigatus from respiratory tract specimens in heart transplant recipients is highly predictive of invasive aspergillosis1

TLDR
The isolation of A. fumigatus from the respiratory tract of a heart transplant recipient is highly predictive of invasive aspergillosis.

Lateral Flow Assays for the Diagnosis of Invasive Aspergillosis: Current Status

TLDR
An update is given on the Aspergillus-specific lateral-flow device (LFD) test, which is based on the JF5 antibody (Ab) and has shown promising results in various studies, and the search for reliable POC tests for other molds continues.

Diagnosis of Invasive Aspergillosis in Lung Transplant Recipients by Detection of Galactomannan in the Bronchoalveolar Lavage Fluid

TLDR
This study reinforces the importance of BAL GM testing in lung transplant recipients, particularly to exclude the diagnosis of IA, and recommends a higher test cutoff should be applied to BAL samples, in comparison with serum samples.

Prospective Assessment of Platelia™Aspergillus Galactomannan Antigen for the Diagnosis of Invasive Aspergillosis in Lung Transplant Recipients

  • S. HusainE. Kwak N. Singh
  • Medicine, Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2004
TLDR
The clinical utility of Platelia™Aspergillus galactomannan antigen for the early diagnosis of invasive aspergillosis was prospectively assessed in 70 consecutive lung transplant recipients and the test demonstrated excellent specificity, but a low sensitivity.

Bronchoalveolar Lavage Galactomannan in Diagnosis of Invasive Pulmonary Aspergillosis among Solid-Organ Transplant Recipients

TLDR
BAL GM testing facilitated more-rapid diagnoses of IPA and the institution of antifungal therapy among non-lung solid-organ transplant recipients and helped to rule out IPA.
...