Current State of Circulating MicroRNAs as Cancer Biomarkers.

  title={Current State of Circulating MicroRNAs as Cancer Biomarkers.},
  author={Yuqing He and Juanjuan Lin and Danli Kong and Mingyuan Huang and Chengkai Xu and T K Kim and Alton Etheridge and Yanhong Luo and Yuanlin Ding and Kai Wang},
  journal={Clinical chemistry},
  volume={61 9},
BACKGROUND Numerous studies have demonstrated the existence of stable regulatory RNAs, microRNAs (miRNAs), in the circulation and have shown that the spectrum of these extracellular miRNAs is affected by various pathologic conditions including cancers. CONTENT Circulating miRNAs have been the focus of numerous cancer biomarker discovery efforts over the past few years; however, a considerable number of these studies have yielded inconsistent and irreproducible findings. Here, we have… CONTINUE READING
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