Current Pharmacological Management of Gastro-Esophageal Reflux in Children

@article{Tighe2009CurrentPM,
  title={Current Pharmacological Management of Gastro-Esophageal Reflux in Children},
  author={Mark Peter Tighe and Nadeem Ahmad Afzal and Amanda Bevan and Robert Mark Beattie},
  journal={Pediatric Drugs},
  year={2009},
  volume={11},
  pages={185-202}
}
Gastro-esophageal reflux (GER) is a common phenomenon, characterized by the regurgitation of the gastric contents into the esophagus. Gastro-esophageal reflux disease (GERD) is the term applied when GER is associated with sequelae or faltering growth.The main aims of treatment are to alleviate symptoms, promote normal growth, and prevent complications. Medical treatments for children include (i) altering the viscosity of the feeds with alginates; (ii) altering the gastric pH with antacids… Expand

Paper Mentions

Interventional Clinical Trial
Gastroesophageal Reflux (GER) is a condition that affects the majority of premature infants that are followed at the Kangaroo Mother Care Program (ambulatory program for preterm infants… Expand
ConditionsGastroesophageal Reflux
InterventionDrug
Diagnosis and Treatment of Gastroesophageal Reflux in Infants and Children.
TLDR
Reflux in infants may be treated with body position changes while awake, lower-volume feedings, thickening agents (i.e., rice cereal), antiregurgitant formula, extensively hydrolyzed or amino acid formulas, and, in breastfed infants, eliminating cow's milk and eggs from the mother's diet. Expand
Gastroesophageal Reflux Disease in Neonates and Infants
TLDR
Effective parental reassurance and education regarding regurgitation and lifestyle changes are usually sufficient to manage infant reflux, and there is insufficient evidence to justify the routine use of prokinetic agents. Expand
Managing gastro-oesophageal reflux in infants
TLDR
Gastro-oesophageal reflux disease in infants describes reflux of gastric contents that causes troublesome symptoms or complications and is sometimes wrongly diagnosed in healthy infants with troublesome but harmless symptoms of “physiological” gastro-oesophical reflux. Expand
Managing gastro-oesophageal reflux in infants
  • Medicine
  • Drug and Therapeutics Bulletin
  • 2009
TLDR
This work considers GORD in infancy (i.e. in those aged 0–12 months), the treatments available and when these are needed, and the drugs used to treat infants with GORD are licensed for this indication. Expand
Momentum Trends in the Management of Gastroesophageal Reflux Disease: A Review
TLDR
A considerable extent of GERD patients keep on having manifestations in spite of ideal PPI treatment, and this has required exploration into the improvement of new medications. Expand
68 – Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children with Complex Airway Disease
TLDR
Gastroesophageal reflux disease, gastrointestinal dysmotility, and Eosinophilic Esophagitis are all entities which can affect children with complex airway conditions and need to be considered when evaluating these patients. Expand
Gastroesophageal Reflux in Critically Ill Children: A Review
TLDR
P pH-metry combined with multichannel intraluminal impedance is the technique of choice for diagnosis and the proton pump inhibitors are the drugs ofchoice for the treatment of GER because they have a greater effect, longer duration of action, and a good safety profile. Expand
Gastroesophageal Reflux in Critically Ill Children: A Review
TLDR
P pH-metry combined with multichannel intraluminal impedance is the technique of choice for diagnosis and the proton pump inhibitors are the drugs ofchoice for the treatment of GER because they have a greater effect, longer duration of action, and a good safety profile. Expand
New Insights in Gastroesophageal Reflux, Esophageal Function and Gastric Emptying in Relation to Dysphagia Before and After Anti-Reflux Surgery in Children
TLDR
Recent data suggest that the selection of patients who will benefit from surgery might be enhanced by automated impedance manometry pressure-flow analysis (AIM) analysis, which relates bolus movement and pressure generation within the esophageal lumen. Expand
Delayed-release oral suspension of omeprazole for the treatment of erosive esophagitis and gastroesophageal reflux disease in pediatric patients: a review
TLDR
Evaluating the efficacy of delayed-release oral suspension of omeprazole in childhood esophagitis in terms of symptom relief, reduction in reflux index and/or intragastric acidity, and endoscopic and/ or histological healing found it highly effective. Expand
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TLDR
Thickened formula reduces regurgitation and alginates and proton pump inhibitors can be used to decrease acid GOR, depending on the severity of the GORD, and side-effects are insufficiently studied. Expand
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TLDR
Clinical studies performed in adults and several studies involving children have demonstrated that the proton pump inhibitors are more effective than the histamine-2 receptor antagonists in the relief of GERD symptoms and healing of erosive esophagitis. Expand
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TLDR
Treatment in children depends on age and GORD severity, and PPIs, in particular omeprazole and lansoprazole, have proven efficacy in infants and children, however, dosages should be adapted in neonates and children under 10 years old. Expand
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TLDR
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TLDR
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TLDR
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Role of Drug Therapy in the Treatment of Gastro-Oesophageal Reflux Disorder in Children
TLDR
The role of different drug classes for treating GORD in children is discussed and the presence of oesophagitis, as documented by endos-copy, suggests the use of antisecretory drugs; H2 receptor antagonists are the first-line agents. Expand
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TLDR
It is concluded that domperidone is a useful and safe agent for treatment of gastroesophageal reflex in infants because it addresses the motility abnormalities inherent in the pathophysiology of the disorder. Expand
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TLDR
Omeprazole is found to be highly effective in this group of patients with severe esophagitis refractory to other measures and safe for short-term use, but further studies are needed to assess long-term safety because the significance of chronically elevated gastrin levels in children is unknown. Expand
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