Current Perspectives in Genetics of “Double-Hit” Lymphoma with Possible Clinical Implications

@article{Song2013CurrentPI,
  title={Current Perspectives in Genetics of “Double-Hit” Lymphoma with Possible Clinical Implications},
  author={Yuan-yuan Song and Ye-hui Tan and Ye Yuan and Wei Guo and Zhen-Yu Pan and Ou Bai},
  journal={Cell Biochemistry and Biophysics},
  year={2013},
  volume={69},
  pages={203-208}
}
This article reviews particular subgroup of B-cell lymphoma, called “double-hit” lymphoma (DHL) because of its distinct aberrations-related genes influencing various processes such as apoptosis, differentiation, and proliferation. Recent studies indicate that tumorigenesis is a complex process involving multiple genes, genetic abnormalities, including gene mutations, deletions, and chromosomal alterations. Chromosomal aberrations are not affecting only basic cellular life preserving activities… CONTINUE READING
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