Current Management of Ethylene Glycol Poisoning

  title={Current Management of Ethylene Glycol Poisoning},
  author={Jeffrey Brent},
  • Jeffrey Brent
  • Published 2012
  • Chemistry, Medicine
  • Drugs
  • Ethylene glycol, a common antifreeze, coolant and industrial solvent, is responsible for many instances of accidental and intentional poisoning annually. Following ingestion, ethylene glycol is first hepatically metabolised to glycoaldehyde by alcohol dehydrogenase. Glycoaldehyde is then oxidised to glycolic acid, glyoxylic acid and finally oxalic acid. While ethylene glycol itself causes intoxication, the accumulation of toxic metabolites is responsible for the potentially fatal acidosis and… CONTINUE READING
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