Current Management of Ethylene Glycol Poisoning

@article{Brent2012CurrentMO,
  title={Current Management of Ethylene Glycol Poisoning},
  author={Jeffrey Brent},
  journal={Drugs},
  year={2012},
  volume={61},
  pages={979-988}
}
  • Jeffrey Brent
  • Published 2012
  • Chemistry, Medicine
  • Drugs
    • Ethylene glycol, a common antifreeze, coolant and industrial solvent, is responsible for many instances of accidental and intentional poisoning annually. Following ingestion, ethylene glycol is first hepatically metabolised to glycoaldehyde by alcohol dehydrogenase. Glycoaldehyde is then oxidised to glycolic acid, glyoxylic acid and finally oxalic acid. While ethylene glycol itself causes intoxication, the accumulation of toxic metabolites is responsible for the potentially fatal acidosis and… CONTINUE READING
    View on Springer
    skat.ihmc.us
    89 Citations
    Highly Influential Citations
    5
    Background Citations
    29
    Methods Citations
    4
    Results Citations
    1
    89 Citations
    Citation Type

    Citation Type

    [CME: Ethylene Glycol Intoxication].
    Ethylene glycol, hazardous substance in the household.
    • 18
    • PDF
    Two Cases of Ethylene Glycol Poisoning Treated Successfully with Haemodialysis
    • 1
    • PDF
    Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol?
    • 45
    Treatment of ethylene glycol and methanol poisoning : why ethanol ?
    • 5
    • PDF
    Acid-base balance in acute ethylene glycol poisoning in rats treated with fomepizole
    Ethylene Glycol Toxicity
    • 1
    Ethylene glycol intoxication following brake fluid ingestion complicated with unilateral facial nerve palsy: a case report
    • 1
    • Highly Influenced
    Massive ethylene glycol poisoning triggers osmotic demyelination syndrome.
    • 8
    Challenges in the diagnosis of ethylene glycol poisoning
    • 24
    • Highly Influenced

    References

    SHOWING 1-10 OF 43 REFERENCES
    Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group.
    • 80
    American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee.
    • 235
    • Highly Influential
    4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man.
    • 92
    Ethylene glycol poisoning: toxicokinetic and analytical factors affecting laboratory diagnosis.
    • 138
    • PDF
    American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning
    • 572
    On the metabolic acidosis of ethylene glycol intoxication.
    • 129
    Ethylene glycol toxicity.
    • K. Bove
    • Chemistry, Medicine
    • American journal of clinical pathology
    • 1966
    • 75
    Intravenous 4-methylpyrazole as an antidote for diethylene glycol and triethylene glycol poisoning: a case report.
    • 37
    Clearance of ethylene glycol by kidneys and hemodialysis.
    • 52
    Antifreeze (ethylene glycol) intoxications in Baltimore. Report of six cases.
    • 14