Current Management of Ethylene Glycol Poisoning

@article{Brent2001CurrentMO,
  title={Current Management of Ethylene Glycol Poisoning},
  author={Dr Jeffrey Brent},
  journal={Drugs},
  year={2001},
  volume={61},
  pages={979-988}
}

• Dr Jeffrey Brent
• Published in Drugs 2001
• DOI:10.2165/00003495-200161070-00006

Ethylene glycol, a common antifreeze, coolant and industrial solvent, is responsible for many instances of accidental and intentional poisoning annually. Following ingestion, ethylene glycol is first hepatically metabolised to glycoaldehyde by alcohol dehydrogenase. Glycoaldehyde is then oxidised to glycolic acid, glyoxylic acid and finally oxalic acid. While ethylene glycol itself causes intoxication, the accumulation of toxic metabolites is responsible for the potentially fatal acidosis and… CONTINUE READING

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