Current Industrial Practices in Assessing CYP450 Enzyme Induction: Preclinical and Clinical

@article{Sinz2008CurrentIP,
  title={Current Industrial Practices in Assessing CYP450 Enzyme Induction: Preclinical and Clinical},
  author={Michael W. Sinz and Gillian Feuer Wallace and Jasminder Sahi},
  journal={The AAPS Journal},
  year={2008},
  volume={10},
  pages={391-400}
}
Induction of drug metabolizing enzymes, such as the cytochromes P450 (CYP) is known to cause drug-drug interactions due to increased elimination of co-administered drugs. This increased elimination may lead to significant reduction or complete loss of efficacy of the co-administered drug. Due to the significance of such drug interactions, many pharmaceutical companies employ screening and characterization models which predict CYP enzyme induction to avoid or attenuate the potential for drug… CONTINUE READING
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