Current Findings and Mechanisms of Action of Disulfiram in the Treatment of Alcohol Dependence.


As an alcohol-aversive agent, disulfiram occupies an exceptional position in the pharmacological relapse prevention of alcohol dependence. In contrast to anti-craving drugs, disulfiram does not modulate neurobiological mechanisms of addiction, but rather works by producing an aversive reaction when combined with alcohol. Therapeutic and adverse effects are… (More)
DOI: 10.1055/s-0042-103592


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