Current European practice in immune tolerance induction therapy in patients with haemophilia and inhibitors.


The management of patients with inhibitors is an important challenge in haemophilia care. The lack of randomized controlled trials means that clinical decisions are generally based on subjective opinions, and purchasers' attention is likely to focus on the costs of treatment. In order to assess the current management of inhibitor patients and use of immune tolerance induction therapy (ITI) in Europe, we performed a survey within a European network of 21 comprehensive care centres from 14 countries (the European Haemophilia Therapy Standardisation Board). The survey identified a total of 381 patients with inhibitors attending the centres, 211 (55.4%) of whom had never been exposed to ITI. Between 1998 and 2003, the centres performed 233 procedures and 114 (48.9%) were successful. The survey demonstrated that dosing, which is the time to start and stop the ITI, the type of concentrate to use and the definition of success varied among the centres. Well-designed trials are warranted to guide decision-making, but in the absence of these studies we have developed consensus guidance for the management of inhibitor patients based on current clinical practice, as identified by the survey, and review of the literature.

Citations per Year

124 Citations

Semantic Scholar estimates that this publication has 124 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Astermark2006CurrentEP, title={Current European practice in immune tolerance induction therapy in patients with haemophilia and inhibitors.}, author={Jan Astermark and Marta Morado and Angiola Rocino and H M van den Berg and Mario von Depka and Alessandro Gringeri and Lorenzo Giovanni Mantovani and Rosario P{\'e}rez Garrido and Mario Schiavoni and {\'A}ngel Ma Villar and J Windyga}, journal={Haemophilia : the official journal of the World Federation of Hemophilia}, year={2006}, volume={12 4}, pages={363-71} }