Current Concepts of Hyperinflammation in Chronic Granulomatous Disease

  title={Current Concepts of Hyperinflammation in Chronic Granulomatous Disease},
  author={Nikolaus Rieber and A Hector and Taco Willem Kuijpers and Dirk Roos and Dominik Hartl},
  booktitle={Clinical & developmental immunology},
Chronic granulomatous disease (CGD) is the most common inherited disorder of phagocytic functions, caused by genetic defects in the leukocyte nicotinamide dinucleotide phosphate (NADPH) oxidase. Consequently, CGD phagocytes are impaired in destroying phagocytosed microorganisms, rendering the patients susceptible to bacterial and fungal infections. Besides this immunodeficiency, CGD patients suffer from various autoinflammatory symptoms, such as granuloma formation in the skin or urinary tract… CONTINUE READING
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Reactive oxygen species-independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease

  • F. L. Van De Veerdonk, S. P. Smeekens, L.A.B. Joosten
  • Proceedings of the National Academy of Sciences…
  • 2010
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