Current Concepts and Translational Uses of Platelet Rich Plasma Biotechnology
@inproceedings{Andia2015CurrentCA, title={Current Concepts and Translational Uses of Platelet Rich Plasma Biotechnology}, author={Isabel Andia and Eva Rubio-Azpeitia and J. I. Martin and Michele Abate}, year={2015} }
A two-decade long research has expedited knowledge about tissue repair mechanisms, and the field of Regenerative Medicine is gaining ground stimulated by novel insights and the development of therapeutic biotechnologies, intending to restore tissue architecture and functionality. Regenerative Medicine technologies concern not only traumatic tissue injuries but also involve the biological manipulation of pathological conditions aiming to drive tissue circumstances to normal, i.e. the recovery of…
23 Citations
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020
- Biology, MedicineInternational journal of molecular sciences
- 2020
Recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing are discussed.
Platelet-inspired therapeutics: current status, limitations, clinical implications, and future potential
- BiologyDrug Delivery and Translational Research
- 2020
This novel approach is designed with the objective that the platelets retain their original structure and functions within the body, thereby mitigating biocompatibility challenges and discussing the clinical implications and future potential of platelet-inspired therapeutics.
A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification
- Medicine, BiologySkin Appendage Disorders
- 2017
The knowledge of the biology, mechanism of action, and classification of the PRP should help clinicians better understand this new therapy and to easily sort and interpret the data available in the literature regarding PRP.
Effects of platelet-rich plasma and platelet-poor plasma on human dermal fibroblasts.
- Medicine, BiologyMaturitas
- 2018
Platelet Rich Plasma, Platelet Lysate, Freeze-dried Platelets and Next
- Medicine, Biology
- 2015
The role of PRP in pain medicine had gained variable acceptance in last few years including condition like osteoarthritis, tendinitis and so on and now puzzle for medical fraternity is to find out the optimal level of growth factors or platelets for particular disease condition.
Platelet-rich Plasma: Three Decades and Ongoing, Do We Have a Conclusion?
- MedicineSuez Canal University Medical Journal
- 2019
PRP is yet to become the standard of care; nevertheless, more clinical studies with longer periods of follow up are needed to understand the best candidate and to determine the best ways to use it to improve healing; it may be an approved practice in the future.
What is the potential use of platelet-rich-plasma (PRP) in cancer treatment? A mini review
- Medicine, BiologyHeliyon
- 2020
CORR Synthesis: What Is the Role of Platelet-rich Plasma Injection in the Treatment of Tendon Disorders?
- MedicineClinical orthopaedics and related research
- 2020
Clinical use of PRP in treatment of tendon pathologies has rapidly expanded, as has research on the topic.
Platelet-rich plasma in the foot and ankle
- Medicine, BiologyCurrent Reviews in Musculoskeletal Medicine
- 2018
Platelet-rich plasma is a promising treatment option, but at present, there is only limited clinical evidence supporting its use in foot and ankle applications.
Easy Platelet-Rich Fibrin (Injectable/Topical) for Post-resurfacing and Microneedle Therapy.
- MedicineFacial plastic surgery clinics of North America
- 2020
References
SHOWING 1-10 OF 107 REFERENCES
Platelet-rich plasma: underlying biology and clinical correlates.
- Biology, MedicineRegenerative medicine
- 2013
Clinical data suggest that PRPs may exploit different regenerative mechanisms under diverse disease conditions, including hemostasis, inflammation, angiogenesis and the synthesis of extracellular matrix.
Partnership between platelet-rich plasma and mesenchymal stem cells: in vitro experience.
- Biology, MedicineMuscles, ligaments and tendons journal
- 2014
We aim to identify current in vitro research exploring platelet-rich plasma (PRP) effects in human Mesenchymal Stem Cells (MSCs) that may encourage or limit the clinical application of MSCs along…
Platelet-rich Plasma for Muscle Injury and Tendinopathy
- MedicineSports medicine and arthroscopy review
- 2013
It is clear that the effectiveness of conservative L-PRP treatments is not proven, and the clinical evaluation of alternative formulations can be extremely informative.
Platelet-Rich Plasma Promotes the Proliferation of Human Muscle Derived Progenitor Cells and Maintains Their Stemness
- Biology, MedicinePloS one
- 2013
Investigating the efficacy of using platelet-rich plasma (PRP) for the ex-vivo expansion of human muscle-derived progenitor cells demonstrated that PRP promoted the proliferation and maintained the multi-differentiation capacities of the hMDPCs during ex- vivo expansion by maintaining the cells in an undifferentiated state.
Effect of neural‐induced mesenchymal stem cells and platelet‐rich plasma on facial nerve regeneration in an acute nerve injury model
- Biology, MedicineThe Laryngoscope
- 2010
The purpose of this study was to investigate the effects of platelet‐rich plasma (PRP) and neural‐induced human mesenchymal stem cells (nMSCs) on axonal regeneration from a facial nerve axotomy…
A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery
- Medicine, BiologyThe International journal of artificial organs
- 1987
A new system for the production of autologous platelet-rich plasma and red blood cell concentrates to be used in autologueous transfusion support of cardiac surgery patients reduced costs andirect costs were reduced since no infective complication was observed due to homologous blood products.
Platelet-rich plasma injections for tendinopathy and osteoarthritis
- Medicine, Biology
- 2012
An overview of the main components of PRP products relevant to the mechanism of action in tendinopathy and osteoarthritis are provided, and the importance of identifying and exploiting principal molecular components in PRP for therapeutic benefit is emphasized.
Platelet-rich plasma for managing pain and inflammation in osteoarthritis
- BiologyNature Reviews Rheumatology
- 2013
Understanding PRP in molecular terms could help to exploit its therapeutic potential, and aid the development of novel treatments and tissue-engineering approaches, for the different stages of joint degeneration.
Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system
- Biology, MedicineExperimental & Molecular Medicine
- 2012
Results indicated that ccdPAs exhibit anti-apoptotic activities, in addition to increased proliferation, when cultured in 2% PRP in comparison to the same concentration of FBS, and that this was accompanied with reduced levels of DAPK1 and BIM mRNA expression in in vitro culture.
Polymeric system for dual growth factor delivery
- Biology, Materials ScienceNature Biotechnology
- 2001
This is the first report of a vehicle capable of delivery of multiple angiogenic factors with distinct kinetics, and these results clearly indicate the importance of multiple growth factor action in tissue regeneration and engineering.