Current Challenges in Antimicrobial Chemotherapy

@article{Bebrone2010CurrentCI,
  title={Current Challenges in Antimicrobial Chemotherapy},
  author={Dr Carine Bebrone and Patricia Lassaux and Lionel Vercheval and Jean-S{\'e}bastien Sohier and Adrien Jehaes and Eric Sauvage and Moreno Galleni},
  journal={Drugs},
  year={2010},
  volume={70},
  pages={651-679}
}
The use of the three classical β-lactamase inhibitors (clavulanic acid, tazobactam and sulbactam) in combination with β-lactam antibacterials is currently the most successful strategy to combat β-lactamase-mediated resistance. However, these inhibitors are efficient in inactivating only class A β-lactamases and the efficiency of the inhibitor/antibacterial combination can be compromised by several mechanisms, such as the production of naturally resistant class B or class D enzymes, the… CONTINUE READING

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