Current Challenges and Trends in the Discovery of Agrochemicals

@article{Lamberth2013CurrentCA,
  title={Current Challenges and Trends in the Discovery of Agrochemicals},
  author={Clemens Lamberth and Stephane Jeanmart and Torsten Luksch and Andrew Plant},
  journal={Science},
  year={2013},
  volume={341},
  pages={742 - 746}
}
Crop protection chemistry has come a long way from its “alchemic” beginnings in the late 19th century to a high-tech science that supports the sustainable production of food, feed, and fiber for a rapidly growing population. Cutting-edge developments in the design and synthesis of agrochemicals help to tackle today’s challenges of weed and pest resistance, higher regulatory safety margins, and higher cost of goods with the invention of selective, environmentally benign, low use rate, and cost… Expand
View on AAAS
ncbi.nlm.nih.gov
250 Citations
Highly Influential Citations
4
Background Citations
39
Methods Citations
2

250 Citations

Citation Type

Citation Type

Progress of modern agricultural chemistry and future prospects.
  • P. Jeschke
  • Business, Medicine
  • Pest management science
  • 2016
TLDR
This review gives a comprehensive overview of the innovative products launched over the past 10 years and describes the progress of modern agricultural chemistry and its future prospects. Expand
Synthetic approaches to the 2010-2014 new agrochemicals.
In this review, the synthesis of 30 agrochemicals that received an international standardization organization (ISO) name during the last five years (January 2010 to December 2014) is described. The… Expand
Synthesis of New Agrochemicals
The constantly growing world population calls for effective means of sustainable food production. This chapter will address some general aspects of the chemical action of products that protect crops… Expand
Propesticides and their use as agrochemicals.
  • P. Jeschke
  • Biology, Medicine
  • Pest management science
  • 2016
TLDR
This review describes comprehensively the successful utilisation of propesticides and their role in syntheses of modern agrochemicals, exemplified by selected commercial products coming from different agrochemical areas. Expand
Chemistry in Agriculture – A Review
Food is the basic requirement for sustenance of human life. Agriculture, for decades, has been closely associated with the cultivation of the soil, production of economically important crops and… Expand
EAST MEETS WEST - REGIONAL IMPACT ON AGROCHEMICAL DISCOVERY AND INNOVATION.
TLDR
It is expected that there will continue to be changes in the numbers and origins of new crop protection compounds, with contributions continuing from Europe, Japan and the US, and increasingly from China. Expand
Harnessing microbial volatiles to replace pesticides and fertilizers
TLDR
This review will highlight recent advances in the understanding of the biological activities of microbial VOCs (mVOCs), providing perspectives on research required to develop them into viable alternatives to current unsustainable seasonal inputs. Expand
Latest generation of halogen-containing pesticides.
  • P. Jeschke
  • Environmental Science, Medicine
  • Pest management science
  • 2017
TLDR
This review gives an overview of the latest generation of halogen-containing pesticides launched over the past 6 years and describes current halogens-containing development candidates. Expand
Biosynthesized Secondary Metabolites for Plant Growth Promotion
TLDR
The benefits and difficulties associated with pseudomonad-based bioinoculants and recent advances toward commercial application of biosynthetic secondary metabolites from these organisms are described. Expand
Controlled release for crop and wood protection: Recent progress toward sustainable and safe nanostructured biocidal systems.
TLDR
The most important BDS vehicles or carriers, their synthesis, the environmental impact of their constituents and interactions with the active components together with the factors that affect their rates of release such as environmental factors and interaction of BDS with the crops or forest products are considered. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 65 REFERENCES
Chemical crop protection research. Methods and challenges
Chemical crop protection, today a well-established technology to support sustainable production of food, feed, and fiber, will continue to play an important role in agribusiness in spite of the… Expand
Chirality and Crop Protection
The modern agrochemical industry is searching, more intensively than ever, for new substances to combat pests (weeds, deleterious insects, plant pathogens, etc.). In the complex and costly selection… Expand
Alkyne chemistry in crop protection.
  • C. Lamberth
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2009
TLDR
An overview is given of the significance of alkyne derivatives in crop protection chemistry and the importance of alkynes as intermediates in the preparation of agrochemicals is demonstrated. Expand
Structure-based design of agrochemicals.
  • M. Walter
  • Engineering, Medicine
  • Natural product reports
  • 2002
TLDR
This review covers recent advances in the structure-based design of agrochemicals, i.e. herbicides, insecticides, and fungicides, as well as reviewing the literature to the present date. Expand
Physical and Molecular Properties of Agrochemicals: An Analysis of Screen Inputs, Hits, Leads, and Products
This work provides a comprehensive overview of agrochemical properties in terms of the way they change during progression from screen hit to product and in terms of their limits as expressed in… Expand
Innovation in Crop Protection: Trends in Research.
  • Stetter, Lieb
  • Political Science, Medicine
  • Angewandte Chemie
  • 2000
TLDR
This review spans the development of the crop-protection industry from its earliest beginnings to the present day and attempts to portray how the research-based crop- protection industry is prepared for current and future challenges. Expand
Process Research on the Synthesis of Silthiofam: A Novel Fungicide for Wheat
The development of an efficient, low-cost synthesis of the novel wheat fungicide silthiofam (1) is described. Improvements to the original Discovery route allowed 300 kg of material to be prepared in… Expand
Chapter 4 Fluorine-Containing Agrochemicals: An Overview of Recent Developments
Abstract The dramatic effect of fluorine on the biological activity of agrochemicals such as herbicides, insecticides, fungicides, and plant growth regulators has earned fluorine a unique place in… Expand
Bioactive Heterocyclic Compound Classes: Agrochemicals
DESCRIPTION The chemistry of heterocycles is an important branch of organic chemistry. This is due to the fact that a large number of natural products, e. g. hormones, antibiotics, vitamins, etc. are… Expand
Combinatorial chemistry in the agrosciences.
TLDR
The article reviews recent applications of combinatorial synthesis in the lead discovery process for new fungicides, herbicides and insecticides and the role and importance of bioavailability guidelines, natural products, privileged structures, virtual screening and X-ray crystallographic protein structures on the design of solid- and solution-phase compound libraries is discussed. Expand
...
1
2
3
4
5
...