Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis.

@article{Rossi2008CuriosityTK,
  title={Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis.},
  author={Franca Rossi and Robert M. Schwarcz and Menico Rizzi},
  journal={Current opinion in structural biology},
  year={2008},
  volume={18 6},
  pages={748-55}
}
Kynurenine aminotransferases are pyridoxal-5'-phosphate-dependent enzymes, which catalyze the synthesis of kynurenic acid, a highly neuroactive metabolite whose impairment is associated with a number of severe brain disorders. Crystallographic studies of these enzymes from different organisms, including humans, have revealed distinctive structural traits of type I and type II kynurenine aminotransferases. A striking difference concerns domain swapping of the N-terminal regions, which play… CONTINUE READING

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