Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature.

Abstract

By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains… (More)
DOI: 10.1016/j.ijantimicag.2012.02.007

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@article{Hiramatsu2012CuringBO, title={Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature.}, author={Keiichi Hiramatsu and Masayuki Igarashi and Yuh Morimoto and Tadashi Baba and Maya Umekita and Yuzuru Akamatsu}, journal={International journal of antimicrobial agents}, year={2012}, volume={39 6}, pages={478-85} }