Curing a viral infection by targeting the host: the example of cyclophilin inhibitors.

@article{Lin2013CuringAV,
  title={Curing a viral infection by targeting the host: the example of cyclophilin inhibitors.},
  author={Kai Lin and Philippe Gallay},
  journal={Antiviral research},
  year={2013},
  volume={99 1},
  pages={68-77}
}
Every step of the viral life cycle is dependent on the host, which potentially can be explored for antiviral targets. Historically, however, drug discovery has focused mainly on viral targets, because of their perceived specificity. Efforts to pursue host targets have been largely hampered by concern over potential on-target toxicity, the lack of predictive… CONTINUE READING