Cure of acromegaly by operative removal of an islet cell tumor of the pancreas.

@article{Caplan1978CureOA,
  title={Cure of acromegaly by operative removal of an islet cell tumor of the pancreas.},
  author={Robert H Caplan and L Koob and R M Abellera and Anthony S Pagliara and K{\'a}lm{\'a}n Kov{\'a}cs and Raymond V. Randall},
  journal={The American journal of medicine},
  year={1978},
  volume={64 5},
  pages={874-82}
}
We studied a 30 year old woman in whom acromegaly was cured by operative removal of a large cystic beta cell adenoma of the pancreas. We detected substantial amounts of immunoreactive human growth hormone (hGH)-like activity in a tumor tissue extract. Extracts of the tumor and a normal human pituitary gland eluted from a Sephadex G-75 column in two identical peaks. Serial dilutions of the tumor extract displaced radioactive 125I hGH parallel to a standard curve. Surprisingly, an extract of a… CONTINUE READING

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