Curdlan activates dendritic cells through dectin-1 and toll-like receptor 4 signaling.

@article{Kim2016CurdlanAD,
  title={Curdlan activates dendritic cells through dectin-1 and toll-like receptor 4 signaling.},
  author={Hyung Sook Kim and Ki Hwan Park and Hong Kyung Lee and Ji Sung Kim and Yong Guk Kim and Jae Hee Lee and Ki Hun Kim and Jieun Yun and Bang Yeon Hwang and Jin Tae Hong and Youngsoo Kim and Sang Bae Han},
  journal={International immunopharmacology},
  year={2016},
  volume={39},
  pages={
          71-78
        }
}
FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells
TLDR
It is identified that FcRγ, but not DAP12, could negatively regulate the Dectin-1 responses in dendritic cells (DCs), and it is demonstrated that the association of phosphatases SHP-1 and PTEN with F cRγ may contribute to the negative regulation of Fc Rγ in DectIn-1 activation in DCs.
Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development
TLDR
It is demonstrated that the presence of Curdlan at the site of infection modulates the course of disease in BALB/c mice and the ligation of Dectin-1 on DCs acts as an important checkpoint in adaptive immunity against L. major and should therefore be considered in future whole-organism vaccination strategies.
Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses
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It is shown that cAMP-PKA-CREB signaling regulates conventional type-2 Dendritic Cells (cDC2s), but not cDC1s and reprograms their Th17-inducing properties via repression of IRF4 and KLF4, transcription factors for Th2 induction.
Studies on the effects of LPS, ß-glucan and metabolic inhibitors on the respiratory burst and gene expression in Atlantic salmon macrophages.
TLDR
The NAD+ content as well as the NAD+ /NADH ratio increased in curdlan and LPS + curdlan-stimulated cells compared to control cells, which indicated increased metabolic activity in the stimulated cells.
IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis
TLDR
It is reported that Epha2 promotes renal immunopathology during disseminated candidiasis and ferroptotic cell death is identified as a critical pathway of Candida-mediated renal immunopathy that opens a new avenue to tackle Candida infection and inflammation.
Immunomodulatory effect of structurally-characterized mushroom sclerotial polysaccharides isolated from Polyporus rhinocerus on bone marrow dendritic cells (BMDCs).
TLDR
The results showed that both mPRSon and PRW could induce phenotypic and functional maturation of BMDCs and it is anticipated that more understanding of the interactions between the sclerotial polysaccharides and their receptors in immune cells can facilitate their future application for cancer immunotherapy.
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