Curcumin uptake and metabolism

@article{Metzler2013CurcuminUA,
  title={Curcumin uptake and metabolism},
  author={Manfred Metzler and Erika Pfeiffer and Simone I Schulz and Julia S. Dempe},
  journal={BioFactors},
  year={2013},
  volume={39}
}
Curcumin (CUR) is the major orange pigment of turmeric and believed to exert beneficial health effects in the gastrointestinal tract and numerous other organs after oral intake. However, an increasing number of animal and clinical studies show that the concentrations of CUR in blood plasma, urine, and peripheral tissues, if at all detectable, are extremely low even after large doses. The evidence and possible reasons for the very poor systemic bioavailablity of CUR after oral administration are… 
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