Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.

Abstract

Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step in the degradation of tryptophan and is strongly induced in interferon-gamma (IFNgamma)-stimulated dendritic cells (DCs). IDO has recently been established as a key enzyme in T-cell suppression-mediated immune tolerance to tumors. STAT1 phosphorylation appears to play an… (More)
DOI: 10.1074/jbc.M807328200

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@article{Jeong2009CurcuminST, title={Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.}, author={Young-Il Jeong and Sang Woo Kim and In Duk Jung and Jun Sik Lee and Jeong Hyun Chang and Chang-Min Lee and Sung Chun and Man-Soo Yoon and Geun Tae Kim and Seok Woo Ryu and Jong-Suk Kim and Yong Kyoo Shin and Won Suk Lee and Hwa Kyoung Shin and Jae-dong Lee and Yeong-Min Park}, journal={The Journal of biological chemistry}, year={2009}, volume={284 6}, pages={3700-8} }