Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

@inproceedings{Zhang2016CurcuminSO,
  title={Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model},
  author={Zhuo Zhang and Daniel J. Leong and Lin Xu and Zhiyong He and Angela A. Wang and Mahantesh S Navati and Sun Jin Kim and David M. Hirsh and John A. Hardin and Neil J. Cobelli and Joel M. Friedman and Hui Bin Sun},
  booktitle={Arthritis research & therapy},
  year={2016}
}
BACKGROUND Curcumin has been shown to have chondroprotective potential in vitro. However, its effect on disease and symptom modification in osteoarthritis (OA) is largely unknown. This study aimed to determine whether curcumin could slow progression of OA and relieve OA-related pain in a mouse model of destabilization of the medial meniscus (DMM). METHODS Expression of selected cartilage degradative-associated genes was evaluated in human primary chondrocytes treated with curcumin and… CONTINUE READING
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