Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling.

@article{Yin2014CurcuminSG,
  title={Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling.},
  author={Haitao Yin and Y. Zhou and Cuixia Wen and Chong Zhou and Wei Zhang and X. Hu and L. Wang and C. You and Junfei Shao},
  journal={Oncology reports},
  year={2014},
  volume={32 4},
  pages={
          1610-6
        }
}
Temozolomide (TMZ), a DNA alkylating agent, represents the most important chemotherapeutic option for the treatment of glioblastoma in the clinic. Despite its frequent use, the therapeutic efficacy of TMZ remains very limited due to its frequent resistance in glioblastoma. Previous evidence suggested that curcumin (CUM), an ingredient of the Indian spice turmeric, is able to sensitize glioblastoma to TMZ treatment. However, the underlying molecular mechanism remains elusive. In the present… Expand
41 Citations
Combination Therapy with Nanomicellar-Curcumin and Temozolomide for In Vitro Therapy of Glioblastoma Multiforme via Wnt Signaling Pathways
  • 6
Therapeutic potentials of curcumin in the treatment of glioblstoma.
  • 14
Role of Sonic hedgehog signaling in cell cycle, oxidative stress, and autophagy of temozolomide resistant glioblastoma
  • 7
  • PDF
Therapeutic Potential of Curcumin in the Treatment of Glioblastoma Multiforme.
  • 13
A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis
  • 1
Effect of curcumin on glioblastoma cells
  • 7
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway.
  • 33
STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
  • 116
  • PDF
The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents
  • 71
Temozolomide: mechanisms of action, repair and resistance.
  • 313
Mechanisms of Disease: temozolomide and glioblastoma—look to the future
  • 123
...
1
2
3
4
...