Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling.

@article{Fu2018CurcuminRP,
  title={Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling.},
  author={Hongbing Fu and Changming Wang and Dejun Yang and Ziran Wei and Jiapeng Xu and Zunqi Hu and Yu Zhang and Weimin Wang and Ronglin Yan and Qingping Cai},
  journal={Journal of cellular physiology},
  year={2018},
  volume={233 6},
  pages={
          4634-4642
        }
}
In this study, we aimed to investigate the effects of curcumin on cell activities of gastric cancer (GC), and the connection between curcumin and P53, as well as, PI3K signaling. This study was conducted with two cell lines SGC-7901 and BGC-823, both were exposed to curcumin at the concentrations of 0, 10, 20, and 40 μm. MTT assay, flow cytometry (FCM) assay, transmission electron microscopy (TEM) were used to study the underlying mechanisms of curcumin in respective of proliferation, apoptosis… CONTINUE READING
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