Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer.

@article{Swarnakar2005CurcuminRE,
  title={Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer.},
  author={Snehasikta Swarnakar and Krishnendu Ganguly and Parag Kundu and Aditi Banerjee and Pallab Maity and Anamika Vivek Sharma},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 10},
  pages={9409-15}
}
Matrix metalloproteinases (MMPs) are suggested to play a critical role in extracellular matrix degradation and remodeling during inflammation and wound healing processes. However, the role of MMPs in indomethacin-induced gastric ulcer and its healing process are not clearly understood. This study is aimed at determining the regulation of MMP-9 and -2 activities in indomethacin-induced acute gastric ulceration and healing. Indomethacin-ulcerated stomach extracts exhibit significant up-regulation… CONTINUE READING