Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor β1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1.

@article{Ma2017CurcuminRC,
  title={Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor β1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1.},
  author={Jin Ma and Shi-yu Ma and Chun-hua Ding},
  journal={Chinese journal of integrative medicine},
  year={2017},
  volume={23 5},
  pages={362-369}
}
OBJECTIVE To study the effect of curcumin on fibroblasts in rats with cardiac fibrosis. METHODS The rats were randomly divided into 4 groups (n=12 in each group): the normal control, isoproterenol (ISO), ISO combined with low-dose curcumin (ISO+Cur-L), and ISO combined with high-dose curcumin (ISO+Cur-H) groups. ISO+Cur-L and ISO+Cur-H groups were treated with curcumin (150 or 300 mg•kg-1•day-1) for 28 days. The primary culture of rat cardiac fibroblast was processed by trypsin digestion… CONTINUE READING
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