Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons.

@article{Wang2010CurcuminPN,
  title={Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons.},
  author={Rui Wang and Yuhua Li and Ying Xu and Ying-bo Li and H Wu and Hao Guo and J Zhang and Jing-jie Zhang and Xue-Yang Pan and Xue-Jun Li},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2010},
  volume={34 1},
  pages={147-53}
}
Curcumin is a major constituent of curcuma longa, a traditional medicine used to manage mental disorders effectively in China. The neuroprotective effects of curcumin have been demonstrated in our previous studies. In the present research, we confirmed this effect by showing that curcumin application promoted the viability of cultured rodent cortical neurons. Moreover, when neurons were pretreated with tyrosine kinase B (TrkB) antibody, known to inhibit the activity of brain-derived… CONTINUE READING